Miniaturized DNA Biosensor for Decentralized Breast-Cancer Screening
Abstract
The use of DNA testing as an important component of breast cancer diagnosis has been increasing rapidly during the l99Os. The goal of this research Is to develop, optimize, and test a miniaturized sensing system for the rapid and relIable genetic screening detection of breast-cancer. In accordance to our original goal our studies have focused on various fundamental and practical aspects of electrical detection of DNA segments specific to the breast-cancer gene BRCAl. We have made a substantial progress and introduced new electrical strategies and routes for improving the reliability of devices for genetic screening of breast-cancer. In particular, we have successfully combined the unique amplification features of new metal nanoparticles or enzyme tags, with an effective magnetic separation (isolation) of the duplex, and a powerful electrical detection for achieving the task of selective and sensitive breast-cancer screening. Additional developmental wort', particularly further improvements in the sensitivity and sample preparation, is in progress towards the realization of wide-scale decentralized screening for breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2001
- Accession Number
- ADA392398
Entities
People
- Joseph Wang
Organizations
- New Mexico State University