Dietary Prevention of Breast Cancer
Abstract
The goal of this Academic Award is to appraise critically the state of dietary prevention of breast cancer and to forge new avenues of investigation in the field of nutrition. This goal consists of two specific aims: (1) to determine the importance of timing of specific dietary exposures on breast cancer risk; and (2) to develop a novel nutrition and cancer program to the Pi's institution. Following achievements have been made towards the aims: (1) the Pi's laboratory is currently focusing on investigating the impact of an exposure, either during in utero period through a pregnant dam, during prepubertal period or during pregnancy, to different types of dietary fats, phytoestrogens and alcohol on breast cancer risk. Since the beginning of the second year of the award period in 7/1/00, these studies have generated 6 published, 2 in press, and 2 submitted papers, and 4 manuscripts in preparation. The studies show That ill utero exposure to n-6 or n-3 polyunsaturated fatty acids (PUFAs), genistein or soy may have opposite effects on mammary tumorigenesis than prepubertal exposures. Human studies have also been completed or in progress to determine whether the findings obtained in animal models are relevant to breast cancer prevention in women. (2) A new course (PI is The course director) entitled "Life style and cancer prevention" was taught for a first time as part of the Tumor Biology graduate program at Georgetown University. In addition, The PI has obtained a planning grant from NCI to develop a program consisting of several RO1 type awards to study The interactions among nutrition, genes and cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2001
- Accession Number
- ADA403634
Entities
People
- Leena A. Hilakivi-clarke
Organizations
- Georgetown University