Integrating Organ Motion and Setup Uncertainty into Optimization of Modulated Electron Beam Treatment of Breast Cancer
Abstract
This project is to develop, implement, and evaluate models of organ motion and setup uncertainty for dose calculation of radiotherapy treatment of the breast. These models are applied to accurate dose calculation for breast treatment using energy- and intensity-modulated electron radiotherapy (MERT). The premise is that MERT treatments will deliver a more conformal dose to the breast while minimizing the dose to normal tissues over conventional photon techniques. We have completed the following tasks: (1) developed theoretical models of organ motion and setup uncertainty based on published data, and (2) implemented those models into a Monte Carlo dose calculation code. We have developed a model of organ motion that correlates the dose in a static computed tomography scan to the actual case of patient breathing. A Gaussian model has been developed to account for setup uncertainty due to the random nature of setup uncertainty in radiotherapy, which has been demonstrated in published literature. These models have been implemented in a Monte Carlo code for radiotherapy dose calculations based on patient specific computed tomography scans. The successful completion of our goals now permits further study (specific aims 3 and 4) on the effect of these effects on MERT radiotherapy breast treatment.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2001
- Accession Number
- ADA406052
Entities
People
- Todd A. Pawlicki
Organizations
- Stanford University