A Multidisciplinary Approach to Generating Effective Therapeutics for Emerging Hantaviruses
Abstract
The major goals of this project are to purify hantavirus proteins (Jonsson) for X-ray structure determination (Arnold). By defining the three-dimensional structures of the N and RDRP proteins of hantaviruses, our studies will afford a means to model drugs that specifically interfere with important stages of viral replication. Particularly, disrupting one or more functions of the RDRP is expected to result in effective disease treatment with little toxicity to host cells. In addition, our research will yield a high through-put in vitro assay for identification of new antiviral drugs. Together, these studies should lead toward effective therapeutic measures for controlling and treating hantaviral infections.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2002
- Accession Number
- ADA406094
Entities
People
- Colleen B. Jonsson
- Edward Arnold
Organizations
- New Mexico State University