PET Radiotracers for Imaging the Proliferative Status of Breast Tumors
Abstract
The goal of this IDEA grant was to prepare a 18F-labeled radiotracer having a high affinity and selectivity for the sigma-2 receptor that can be used for Positron Emission Computed Tomography (PET) imaging studies of breast cancer. Our choice of this receptor system stems from the observation that there is a high density of sigma2 receptors in both murine and human breast cancer cells in vitro. In addition, we have reported that the density of sigma2 receptors is about 10 times greater in proliferative mouse breast tumor cells than on quiescent mouse breast tumor cells in both cell cultures and in solid breast tumors growing in nude mice. These data suggest that a 18F-labeled sigma2 radiotracer should have the potential to both image breast tumors and assess the proliferative status of these tumors in vivo with PET.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2002
- Accession Number
- ADA406848
Entities
People
- Robert H. Mach
Organizations
- Wake Forest University