Development of Potent Orally Active Agents for Prevention and Treatment of Poxvirus Infection

Abstract

Smallpox (variola major) is estimated to have killed a billion persons over the past 200 years. Vaccination eliminated the disease from the earth in the late 1 970s (WHO) but stocks of smallpox have been retained by the US and Russia at safe locations. However, rogue states such as Iraq, North Korea, Iran or terrorist groups may also have stocks of smallpox which could be used in biowarfare or bioterrorism. In the late 80s, Russia produced tons of variola, India-i, for use in long range ICBMs (Alibek) and it is uncertain what has become of those stocks and the thousands of persons trained to produce the variola virus.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2002
Accession Number
ADA410484

Entities

People

  • James R. Beadle
  • Karl Y. Hostetler

Tags

DTIC Thesaurus Topics

  • Anti-Infective Agents
  • Antiviral Agents
  • Chemical Synthesis
  • Chemistry
  • Chemotherapy
  • Electrospray Ionization
  • Health Services
  • Hiv Infections
  • Indicator Dyes
  • Infection
  • Liquid Chromatography
  • Pharmacology
  • Poxviridae Infections
  • Rodents
  • Virus Diseases
  • Viruses

Readers

  • Infectious Disease/Epidemiology
  • Nuclear Non-Proliferation and International Security
  • Strategic Security Studies

Technology Areas

  • Biotechnology