Magnetic Resonance Spectroscopy of Breast Cancer
Abstract
We have developed a unique magnetic resonance imaging multi voxel pulse sequence unaffected by intravenous contrast producing spectroscopic images of key metabolites (choline) found in breast cancer, and validated our work in 22 breast lesions with in vitro spectra and pathology. Choline peaks are present in 57% of breast cancers but contrary to other research data some invasive ductal cancers do not contain choline as a detectable metabolite, particularly in lobular cancer that has dispersed cells. Furthermore, benign fibrocystic change/fibrosis, hamartomas and patients with silicone injections may have detectable choline from increased metabolic activity not due to malignancy. Thus, technical developments to date have significantly contributed towards the goal of making MR spectroscopic imaging a clinically useful procedure that could be implemented at the time of a contrast-enhanced MRI scan but would be helpful only in choline positive cases to prompt biopsy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2002
- Accession Number
- ADA412988
Entities
People
- Debra M. Ikeda
Organizations
- Stanford University