Combining Electron With Intensity Modulated Photon Beams for Breast Cancer
Abstract
A hybrid breast cancer treatment technique using electron and intensity modulated photon was developed. The technique took advantage of the useful features of the two types of beams and showed significant promise to improve the current breast irradiation technique. Technically, the weight of the electron beam and the fluence profiles of the IMRT beams were optimized simultaneously with the goal of generating a uniform composite dose distribution in the target volume. We have (i) developed an effective algorithm for the hybrid optimization with the regional dose modifiable by a reginal penalty scheme; (ii) explored the feasibility of further improving the technique by intensity- and energy- modulate the electron beam; (iii) developed software to incorporate MLC transmission and head scatter into IMRT delivery to ensure accurate dose delivery; (iv) demonstrated the dosimetric advantage of the hybrid approach; (v) evaluated the matching of electron and IMRT beams against the setup errors; and (vi) explored the feasibility of combining intensity- and energy-modulate electron beam and IMRT for breast irradiation. The development provides a viable alternative for clinically difficult breast cases. Using he technique, the high doses to the lung and heart were markedly reduced with minimal increase in the dose to other normal structures.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA418907
Entities
People
- Lei Xing
Organizations
- Stanford University