Characterization of Genetic Alterations in Ovarian Cancer
Abstract
The goal of this Program Project was to utilize genetic technologies to begin to understand the important changes that underlie ovarian cancer development. Utilizing transcriptional profiling to ascertain consistently up-and down-regulated genes, we began to characterize ovarian epithelial cancer. We had three interactive projects in this Program Project. The first project, headed by Dr. Viji Shridhar, had its major aim the identification of genes that were consistently down-regulated during ovarian cancer development. Dr. Shridhar also led the efforts to transcriptionally profile the ovarian tumors and she has now identified a number of interesting and promising candidates. Dr. Fergus Couch focused on characterizing gene amplification in familial and sporadic ovarian tumors, also utilizing the database of gene expression that we obtained for the ovarian tumors. Dr. David I. Smith focused on the characterization of the highly active common fragile site, FRA6E. They also analyzed genes consistently down-regulated in ovarian tumors that were derived from chromosomal regions containing common fragile sites. They were able to identify a number of previously uncloned common fragile sites and identify important genes in those regions. We have begun to unravel the complex genetic changes that underlie the development of this aggressive cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2003
- Accession Number
- ADA421954
Entities
People
- David I. Smith