Summer Student Breast Cancer Research Training Program
Abstract
The purpose of the breast cancer research-training program is to recruit and train potential future researchers in breast cancer research. We recruited 15 individuals, interviewed eight, and chose five for the program. During the 12-week program, trainees attended seven lectures dealing with research, participated in weekly research meetings, and developed and carried out separate research projects under the supervision of their rese%rch mentors. Two projects involved study of the anticancer properties of Ganoderma lucidium-(GL), a medicinal mushroom. GL was found to inhibit estrogen receptor signaling in breast cancer cells. Two projects studied the effects of omega-3 long chain polyunsatureated fatty acids (O3FA). O3FA (notably methyl esters of the lipids) were found to inhibit proliferation of an proteolysis induced by breast cancer cells. A fifth project evaluated the effect of C-reative protein (CRP), an important inflammatory molecule upon protein markers of cancer invasiveness. CRP was found to stimulate expression of urokinase plasminogen activator and its receptor. These results provide the basis for ongoing research projects. The results have added significant new information to our understanding of dietary modulation of breast cancer cell proliferation and invasion and provide a basis for further studies of dietary modulation of breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2004
- Accession Number
- ADA425839
Entities
People
- Gary P. Zaloga
Organizations
- Indiana University Health