Effect of Pretreatment With Human Butyrycholinesterase Scavengers on the Toxicokinetics and Binding of Nerve Agents in Guinea Pigs and Marmosets
Abstract
An effective therapy against intoxication with nerve agents has been developed involving combined administration of atropine, oxime and anticonvulsant. Administration of the therapeutic agents almost immediately after intoxication is a prerequisite for their efficacy, which renders this approach less satisfactory under field conditions. The treatment is a fortiori much less effective if the nerve agent forms an inhibited acetylcholinesterase (AChE) that is, or rapidly becomes, resistant to reactivation by an oxime. Furthermore, even if the treatment would protect against the lethal effects of nerve agent intoxication, the combined administration of atropine, oxime and anticonvulsant does not prevent the occurrence of post-exposure incapacitation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2005
- Accession Number
- ADA431742
Entities
People
- Jan P. Langenberg
Organizations
- Prins Maurits Laboratorium TNO