Effect of Depleting Tumor-Associated Macrophages on Breast Cancer Growth and Response to Chemotherapy

Abstract

Tumor-associated macrophages (TAM) may comprise up to 50% of the tumor mass in breast cancer and are capable of producing estrogen and angiogenic cytokines that regulate the growth and angiogenesis of breast cancer. The goal of this project is to determine whether depletion of TAM, achieved by intra-tumoral injection of lposome-encapsulated dichioromethylene diphosphonate (clodronate), can slow tumor growth and improve the outcome of breast cancer treatment. Preliminary studies so far have revealed that daily intra-tumoral injection of liposome-encapsulated clodronate had no effect on the growth of subcutaneous breast cancer (4T1) model in mice. Whether liposome-encapsulated cloronate depletes tumor-assocaited macrophages in this model is currently under investigation.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2004
Accession Number
ADA431790

Entities

People

  • Min-fu Tsan

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biological Staining And Labeling
  • Biomedical Research
  • Body Weight
  • Breast Cancer
  • Cells
  • Chemotherapy
  • Counting Methods
  • Electronic Mail
  • Growth Factors
  • Immunostaining
  • Macrophages
  • Medical Personnel
  • Neoplasms
  • Proteins
  • Synthetic Membranes
  • Therapy

Readers

  • Allergy and Immunology.
  • Immunology
  • Molecular Biology and Genetics