Targeting Stromal Recruitment by Prostate Cancer Cells

Abstract

Sonic hedgehog(shh)overexpression in LNCaP cells accelerates tumor growth. To characterize the contributions of each Gli gene to Shh-induced tumor growth, Gli1, Gli2 and Gli3 knockout UGSM cells have been isolated and UGSM-2 cells independently over-expressing hGli1 and hGli2 were cloned. Experiments using those cell lines co-injected with LNCaP cells in the Xenograft model indicate stromal Shh signaling activation may play an important role in the tumor growth.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2006
Accession Number
ADA462917

Entities

People

  • Jingxian Zhang

Organizations

  • University of Wisconsin–Madison

Tags

DTIC Thesaurus Topics

  • Alkaloids
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Culture Techniques
  • Cultured Cells
  • Embryos
  • Environmental Health
  • Epithelial Cells
  • Fibroblasts
  • Gene Expression
  • Neoplasms
  • Nervous System Malformations
  • Prostate Cancer
  • Statistical Analysis
  • Tumor Cell Line

Readers

  • Molecular Biology and Genetics