Prostate Cancer Gene Discovery Using ROMA
Abstract
The authors hypothesize that a subset of men who develop prostate cancer do so as a result of an inherited chromosomal deletion or amplification, affecting the function of one or more critical prostate cancer susceptibility genes. These chromosomal abnormalities, and the affected gene(s) can be identified using the novel technique, ROMA. Together with their collaborators at Cold Spring Harbor, they have now performed ROMA analysis of 90 prostate cancer patients, each with a strong family history of prostate cancer (having at least two affected first-degree relatives). The majority of these men had either early onset prostate cancer (diagnosis before age 60) or evidence of advanced disease (non-organ confined disease). Over 1,100 copy number polymorphisms (CNPs), including many recurring CNPs, have been observed in these 90 patients. These CNPs include 33 novel CNPs that have never (or rarely) been seen in control samples. Of these 33 novel CNPs, one can rule out a causal role for at least 5 based on lack of cosegregation with disease in families in which multiple affected members have been subjected to ROMA analysis. An additional 15 novel CNPs do not affect the coding sequences of any known genes. Currently, the authors are examining both common and rare CNPs in additional cases and controls for evidence of an association with prostate cancer risk.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2006
- Accession Number
- ADA468543
Entities
People
- William B Isaacs
Organizations
- Johns Hopkins University