Combined Contrast-Enhanced MRI and Fluorescence Molecular Tomography for Breast Tumor Imaging
Abstract
Fluorescence molecular tomography is an emerging technology to image the spatial distribution of fluorescence activity in tissue volumes with the potential to reduce false positive readings and eliminate the need for stressful biopsy procedures for many women. However the spatial resolution and quantification capabilities of FMT must be improved before realizing this potential. The funded research aims to improve the imaging capabilities of FMT by incorporating the optical imaging system directly into a clinical MRI for simultaneous image acquisition. Tissue structural information from the MR image is then used to guide the FMT image reconstruction algorithm. This approach is shown to dramatically improve image quality and fluorescence yield quantification in realistic simulated domains and provide noticeable improvements for simple domains in preliminary phantom experiments. Additionally a newly developed algorithm to quantify exogenous absorption is developed and validated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2007
- Accession Number
- ADA468681
Entities
People
- Scott C. Davis
Organizations
- Dartmouth College