A Method for the Analysis of Tabun in Multisol Using Gas Chromatographic Flame Photometric Detection

Abstract

In the past we have found tabun (GA) in saline at 2 microgram/ml to be stable for only a month or less at -70 degrees C. Previous studies have shown that Multisol provides stable solutions of GA. We confirmed the stability of GA in Multisol with phosphorus nuclear magnetic resonance and developed a method for the analysis of GA in Multisol using gas chromatographic flame photometric detection (GCFPD) in the phosphorus mode. The GC method used acetonitrile (CH3CN) for a dilution solvent because of its miscibility with GA in chloroform (CHC13) standards and GA in Multisol samples at 1% (v/v). Furthermore, the dilutions with CH3CN made the phosphorus mode interference peak present in CHC13 analytically manageable, reduced the interferences of Multisol in the GC separation, and contributed to a safe and reliable analysis of GA at 20 microgram/ml. We demonstrated the stability of GA in Multisol stored for more than a year at -70 degrees C. This method contributes a suitable technique for the preparation and analysis of reliable solutions of GA in nerve agent medical research and demonstrates the extended stability of GA in Multisol.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2006
Accession Number
ADA469216

Entities

People

  • Austin T. Swift
  • Edward D. Allen
  • Mark R. Way
  • Sunil-datta Soni
  • Thomas P. Logan

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acetonitrile
  • Alcohols
  • Aqueous Solutions
  • Biomedical Research
  • Chemical Shifts
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemical Weapons
  • Chloroform
  • Detection
  • Dilution
  • Magnetic Resonance
  • Nerve Agents
  • Nuclear Magnetic Resonance
  • Phosphorus
  • Resonance
  • Standards

Fields of Study

  • Biology

Readers

  • Analytical Chemistry