Non-Invasive Monitoring for Optimization of Therapeutic Drug Delivery by Biodegradable Fiber to Prostate Tumor
Abstract
Chemotherapeutic drugs delivered by systematic administration exhibit great toxicity; patients have to endure suffering from frequent injection or low dose IV treatment. Thus controlled release and of these drugs and real-time monitoring of the effects of the drug can be an better treatment modality. The Hypotheses are (1): A near-infrared (NIR) imager can non-invasively monitor the vascular oxygenation and blood volumes in prostate tumors. (2): The dynamic response of prostate tumor oxygenation to the chronic drug delivery can serve as indicator for treatment prognosis. (3): The control of drug delivery rate will have a significant impact on the treatment prognosis. The specific aims of the of the project are: (1): To design and implement a NIR spectroscopic imaging system. (2): To develop imaging of drug concentration and tumor oxygenation. (3): To control the delivery of drug using a novel implantable micropump (IDDS).(4): To study the relationship between drug release rate, tumor oxygen levels and therapeutic outcome. (5): To create appropriate cancer tumor animal models, that will guide the growth of cancer tumor in Copenhagen rats.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2007
- Accession Number
- ADA470936
Entities
People
- Dan Popa
- Hanli Liu
- Liping Tang
Organizations
- University of Texas at Arlington