Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors
Abstract
The overall purpose of this research is to develop a polymeric drug delivery system containing magnetic resonance contrast agents for the treatment of breast cancer. This drug-imaging agent delivery system will allow the follow up of the fate of the drug delivery system and its relation to reduced tumor mass, improved efficacy and reduced toxicity in individual patients. In three years, progress was made in the following areas: 1) Synthesis, characterization, relaxivity and stability measurements of polymer-nitroxide/dinitroxide conjugates. 2) Synthesis, characterization, relaxivity measurement, pH stability measurement, challenge study in the presence of a different chelator and cytotoxicity test of polymer-gadolinium conjugates with and without doxorubicin on cancerous and non-cancerous cell lines. In addition, a series of polymer- contrast agent conjugates targetable to macrophages were synthesized, characterized, and evaluated in vitro. A no cost extension is requested to complete the project.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2007
- Accession Number
- ADA472764
Entities
People
- Bahar Zarabi
- Hamid Ghandehari
Organizations
- University of Baltimore