Synthesis of Cryptophycin Affinity Labels and Tubulin Labeling
Abstract
Cryptophycins are a potent tumor-selective class of tubulin-binding antimitotic anti-cancer agents with excellent activity against MDR cancers. In order to develop these promising compounds into useful chemotherapeutic agents it is necessary to obtain detailed information about the binding domain of the cryptophycins on tubulin. We plan to map the cryptophycin binding site through photoaffinity labeling studies. Toward this goal, we have synthesized and studied the activity of C16 side chain azido analogues and synthesized C6 dimethyl and C10 azido analogues of cryptophycin-24, by means of inventing an improved synthetic route to achieve the synthesis of diverse analogues in a more efficient way.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2006
- Accession Number
- ADA474734
Entities
People
- Gunda I. Georg
- Kyounglang Yang
Organizations
- University of Kansas