Optimizing and Evaluating an Integrated SPECT-CmT System Dedicated to Improved 3-D Breast Cancer Imaging
Abstract
The overall objective of this research is to optimize the development of a combined dual-modality single photon emission computed tomography (SPECT) and x-ray computed mammotomography (CmT) system for the earlier detection and staging of breast cancer, improving surgical biopsy guidance, and the monitoring of patient therapy response. Co-registered acquisition of emission (nuclear) and transmission (x-ray) data using both 3D imaging modalities in a common field of view may aid to accurately localize the radioactive tumor uptake in the emission image by using anatomical structure from the transmission image. In the first year of this grant the complete hybrid imaging system, including a custom designed patient bed, were successfully integrated and used to complete single and dual-modality patient imaging studies. The tradeoffs inherent in the design of the custom-made bed for prone-patient imaging were investigated by evaluating the effects of limited angle tomography on reconstructed CmT image quality of the pendant breast volume. Novel 3D system trajectories to help overcome the design tradeoffs were also investigated with an observer study used to quantify the results. Initial steps in the process of designing a fully integrated imaging system with both modalities capable of full 3D motion were also taken. In addition to research, experience in other areas of breast cancer screening and detection were explored through shadowing clinical procedures.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2009
- Accession Number
- ADA506446
Entities
People
- Dominic J. Crotty
Organizations
- Duke University