MR-Guided Near Infrared Spectroscopy for Reducing Breast Cancer False Positives

Abstract

This project investigated the relationship between optical and magnetic resonance (MR) breast imaging, with the goal of reducing false positives resulting from MR mammography. MR-guided Diffuse Optical Imaging (MRg-DOI), which combines the high sensitivity of breast MR with quantitative images of tissue physiology, may improve differentiation between benign and malignant lesions. This work developed a unique MR breast coil-coupled fiber interface to improve data quality and increase the adjustability of fiber positioning. This platform enabled multi-planar, patient-specific fiber arrangements to optimize data quality. To correct for the deficiencies of optical photodetectors in quantifying water, MR water/fat (DIXON) imaging was used to reduce hemoglobin/water crosstalk and improve hemodynamic quantification by at least 20%. Next, this study investigated the correlation between hemodynamics determined both optical imaging and MRI. This work was the first demonstration of optical tomography and Blood Oxygen Level Dependent (BOLD) MRI in the breast. Results showed significant correlation in a study population of 13 women (p<0.05) when the appropriate respiratory challenge was used. Additionally, the respiratory challenge showed promise in imaging tumor vasculature characteristics in breast cancers. To comprehensively merge the MR data and optics, a combined optical/MR image reconstruction model was developed. This formulation provides a foundation to characterize breast lesions with higher temporal, spatial, and functional information than was previously available. In case studies, the MR-guided optical system correctly characterized malignant lesions, and in one case, correctly assessed a tissue region that was incorrectly identified by MRI as malignant.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2009
Accession Number
ADA520092

Entities

People

  • Colin Carpenter

Organizations

  • Dartmouth College

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood Flow
  • Breast Cancer
  • Cancer
  • Detection
  • Detectors
  • Drug Therapy
  • Health Services
  • Image Reconstruction
  • Laser Diodes
  • Magnetic Resonance
  • Measurement
  • Medical Personnel
  • Neoplasms
  • Optical Detectors
  • Optical Properties
  • Three Dimensional
  • Tomography

Fields of Study

  • Medicine
  • Physics

Readers

  • Computational Modeling and Simulation
  • Medical Imaging.