Onboard SPECT for Localizing Functional and Molecular Targets in Metastatic Breast Cancer
Abstract
The overall goal of this work is to assess the potential performance characteristics of using single photon emission computed tomography (SPECT) for imaging inside radiation therapy treatment rooms to localize functional & molecular targets associated with metastatic breast cancer. The first aim is to evaluate localization accuracy and precision as a function of scan time, tumor size, tumor-to-background uptake ratio, and background non-uniformity. This aim was addressed using computer-simulation and hardware studies. The second aim involves the localization of breast metastases in lung. Through computer simulations, we studied localization performance of tumors in the lungs and other sites as a function of spatial resolution modeling, observer normalization, iteration number, and post-reconstruction smoothing. Localization errors were also analyzed for directional dependencies in relation to the detector trajectory.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2010
- Accession Number
- ADA542621
Entities
People
- Justin R. Roper
Organizations
- Duke University