A Brain-Machine-Brain Interface for Rewiring of Cortical Circuitry after Traumatic Brain Injury

Abstract

Using a controlled cortical-impact device, we have successfully induced traumatic brain injury (TBI) in the caudal forelimb area (CFA) of the rat brain, sparing the rostral forelimb area (RFA) that is the target for implantation of the electronic microsystem. Behavioral assessments of reaching, retrieval of small food items, and locomotion demonstrate that deficits persist during the 5- week recovery period following injury. Further, an unprecedented, potent effect of activity-dependent stimulation (ADS) between the RFA and primary somatosensory forelimb area in brain-injured rats has been demonstrated by 5 days post-lesion.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2011
Accession Number
ADA561375

Entities

People

  • Randolph J Nudo

Organizations

  • University of Kansas Medical Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animal Structures
  • Brain
  • Brain Injuries
  • Central Nervous System
  • Cerebral Cortex
  • Computer Programs
  • Department Of Defense
  • Motor Skills
  • Nervous System
  • Neurons
  • Prosthetics
  • Rodents
  • Skull
  • Statistical Analysis
  • Surgery
  • Training
  • Wounds And Injuries

Fields of Study

  • Biology
  • Psychology

Readers

  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.

Technology Areas

  • Microelectronics