Validation of an In Vitro Bioaccessibility Test Method for Estimation of Bioavailability of Arsenic from Soil and Sediment

Abstract

A method is described for measuring the in vitro bioaccessibility (IVBA) of arsenic in soil or soil-like media, and using the measured IVBA value to estimate the relative bioavailability (RBA) in swine or monkeys using empiric regression models developed from 20 (swine) or 17 (monkey) calibration soils. The correlation coefficients for the models are high (0.85 for swine, 0.87 for monkey), and the precision of the method is high, both within and between laboratories. This method is the most thoroughly tested, calibrated, and validated IVBA approach for estimation of arsenic RBA that has been described to date.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2012
Accession Number
ADA579125

Entities

People

  • Susan Griffin
  • Yvette Lowney

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Accuracy
  • Arsenates
  • Arsenicals
  • Chemical Speciation
  • Chemical Synthesis
  • Chemistry
  • Digestive System Processes
  • Earth Sciences
  • Ecology
  • Environmental Protection
  • Health Services
  • Information Science
  • Measurement
  • Medical Personnel
  • Regression Analysis
  • Spreadsheet Software
  • Test Methods

Readers

  • Computational Modeling and Simulation
  • Data Mining and Knowledge Discovery.
  • Environmental Engineering