Challenges of Zinc-Specific Transrectal Fluorescence Tomography to Detect Prostate Cancer
Abstract
The project studied the challenges of trans-rectal FDOT of negative-contrast targets relating to zinc-specific fluorophore. (1). Algorithms to enable trans-rectal FDOT reconstruction are developed, and synthetic FDOT study are performed to assess how sensitive the trans-rectal fluorescence measurement is to a "negative-contrast" fluorescence target. (2). A novel geometric-sensitivity-difference method is introduced to improve target depth localization for trans-rectal fluorescence diffuse optical tomography. (3) A novel analytical approach has been developed to quantifying the diffuse photon propagation in an outward-imaging geometry that idealize transrectal optical imaging. (4) Numerical studies have demonstrated that and detecting a target of negative-contrast in the trans-rectal prostate-imaging geometry is especially challenging. (5) Experimental works are conducted to test the feasibility of TRUS-coupled FDOT of tissue phantoms containing target of positive or negative fluorescent contrast over the background. (6) A routine is developed to use sparsely 2D TRUS images to synthesize the 3D prostate profile to improve the image reconstruction.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2013
- Accession Number
- ADA599543
Entities
People
- Anqi Zhang
- Daqing Piao
Organizations
- Oklahoma State University–Stillwater