Threshold-Switchable Particles (TSP's) to Control Internal Hemorrhage

Abstract

The final goal of our research is to develop smart particles to stop internal hemorrhage at local sites. To accomplish this goal, we are combining multiple approaches in four collaborating laboratories to define threshold levels of activators of blood clotting such that the candidate clotting activators will circulate in the blood at below the threshold necessary to trigger clotting, but accumulation of the activators at sites of internal injury/bleeding will cause the local concentration of clotting activators to exceed the clotting threshold and restore hemostasis. The approaches being used include the development of novel chemistries for attaching inorganic polyphosphate (polyP; a potent trigger and accelerator of blood clotting) to nanoscale solid supports, development of candidate nanoparticles with varying abilities to trigger and/or accelerate blood clotting, and defining the threshold levels under which these particles will or will not trigger blood clotting.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2011
Accession Number
ADA612344

Entities

People

  • James H Morrissey

Organizations

  • University of Illinois Urbana–Champaign

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood
  • Blood Coagulation
  • Blood Coagulation Factors
  • Chemical Synthesis
  • Chemistry
  • Composite Materials
  • Contracts
  • Department Of Defense
  • Hemostasis
  • Materials
  • Materials Laboratories
  • Materials Processing
  • Materials Science
  • Materials Testing
  • Metallic Nanoparticles
  • Particle Size
  • Particles

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Nanocomposite Materials Science
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology