Investigations Concerning Hydrolysis and Stabilization of Antiradiation Compounds
Abstract
This report covers studies conducted on S-2-(3-aminopropylamino)- ethylphosphorothioic acid, WR 2721, over the period January 16, 1981 through January 15, 1982. The most significant results obtained during this report period are the following. (1) Unencapsulated WR 2721 was found to be hydrolytically stable over the pH range of 7.4 to 11.0. (2) WR 2721 was successfully encapsulated in certain matrices such that the WR 2721 was not significantly hydrolyzed in 1.5 hours at 37 C in buffered solutions of pH 1.0 or 3.0. (3) The more promising microspheres and microcapsules released the WR 2721 within two hours at pH 7.5 in buffered solutions. (4) Analytical procedures were developed for: WR 2721 (directly) in microcapsules using an HPLC procedure; WR 2721 (directly) in buffered solution (pH 7.4) using an HPLC procedure; WR 2721 (indirectly) in synthetic intestinal fluid using an HPLC procedure based upon a derivatization of WR 2721 with o-phthalaldehyde. (5) An analytical procedure is being investigated for the analysis of blood plasma for WR 2721 and its mercaptan and disulfide. At present, it appears that a method based on derivatizing the species with fluorescamine is most promising.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1982
- Accession Number
- ADB080528
Entities
People
- C. W. Lew
- D. J. Mangold
- E. M. Gause
- N. F. Swynnerton
Organizations
- Southwest Research Institute