Innovative Design and Synthesis of Antiparasite Agents
Abstract
Malaria is a global health problem and remains a significant health problem for US military forces deployed to the tropics and subtropics. Existing antimalarial agents are either toxic or of diminished efficacy. We have discovered a new and novel class of antimalarial drugs which inhibit the process of heme polymerization. Extensive synthesis of analogs of the parent compound, X5, provided critical information on the structure-activity relationships which govern activity. Based on the knowledge gained from these studies we have now employed computer assisted drug design to produce drugs with enhance selectivity and potency.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1997
- Accession Number
- ADB227768
Entities
People
- Michael K. Riscoe