Mitigate (ATD)
Abstract
The Mitigate Advanced Technology Development (ATD) Project provides the Joint Force the ability to preserve combat power by mitigating exposure to chemical and biological (CB) hazards and restoring combat readiness of critical personnel and platforms. In FY 2023, the Chemical Biological Defense Program (CBDP) RDT&E Projects were restructured to align with the CBDP portfolio construct. MT3 efforts in FY 2022 remain in Projects CB3 and TM3. This restructuring provided standardization and alignment across CBDP research, development and acquisition efforts. Thrust Areas included in this Project are: (1) Biological Warfare Defense Therapeutics (2) Discovery of Medical Countermeasures Against New and Emerging (DOMANE) (3) Chemical Reactive Ocular Wound and Dermal Therapeutics (CROWD) (4) Emerging and Pharmaceutical-based Agent Threats (EMPATH) (5) Reactivators of Acetylcholinesterase as Therapeutics (ReACT) (6) Enhanced Survivability Coatings (7) Equipment Decontamination (8) Multifunctional Materials for Protection (9) Personnel Decontamination (10) Wide Area Decontamination Biological Warfare Defense Therapeutics: Develops broad-spectrum bacterial, toxin and viral therapeutics, and label expansion (repurposing) of medical countermeasures that are Food and Drug Administration (FDA) approved or in advanced stages of clinical development. These efforts are coordinated with Department of Health and Human Services (HHS), Biomedical Advanced Research and Development Authority (BARDA), and across the interagency and Department, to leverage public and force/defense health related investments made to minimize risk and speed approval of novel antibiotic countermeasures. Efforts include additional investments in enhanced biodefense and pandemic preparedness. Discovery of Medical Countermeasures Against New and Emerging threats (DOMANE): Provides innovative and rapid medical countermeasures (MCMs) development capabilities that reduce developmental risks, cost and schedule associated with MCM fielding, and afford protection against and allow the Joint Force to rapidly respond to traditional, new and emerging biological warfare threat exposures to allow freedom of action. Efforts include additional investments in enhanced biodefense and pandemic preparedness. Chemically Reactive Ocular Wound and Dermal Therapeutics (CROWD): Develop a fielded medical countermeasure for the Warfighter that can treat a chemical agent that has breached the skin. Collect the data that the Food and Drug Administration (FDA) will require for approval. Emerging and Pharmaceutical-based Agent Threats (EMPATH): Assess candidate MCMs (Medical Countermeasures) for development into fieldable drug products. Activities focus on assessing current therapeutic drugs for protection against opioid agents and developing MCMs to treat non-opioid sedatives. Reactivators of Acetylcholinesterase (AChE) as Therapeutics (ReACT): Develops broad-spectrum, centrally-acting acetylcholinesterase (AChE) reactivators, that increase survival, reduce morbidity, and decrease neurological damage. Two advanced lead candidates are in development. Enhanced Survivability Coatings: Addresses military equipment coating ease of decontamination and resistance to chemical agent penetration. Projects will develop temporary coatings that resist chemical agent absorption and are quickly decontaminated in the field and allow the rapid regeneration of combat power. Equipment Decontamination: Develops decontaminant formulations and procedures that reduce or eliminate residual contamination hazards; enables unit-level decontamination with rapid unmasking; reduces logistic needs, enables rapid sorting of clean from dirty to return high-value equipment to normal use, and develops improved realistic test methods. Efforts address the capability to decontaminate personal equipment. Efforts include additional investments in enhanced biodefense and pandemic preparedness. Multifunctional Materials for Protection: Discovers, develops and integrates novel, reactive/catalytic materials and scale material manufacturing with maximum sorption and reactivity, and characterize materials using state-of-the-art in operando and ambient pressure spectroscopies, for eventual integration into next generation decontaminants that reactively decontaminate chemical warfare agents. Personnel Decontamination: Develops personnel decontaminants with lower lifecycle costs and storage constraints and determines time, efficacy, and logistics burdens to Warfighters for mass casualty decontamination, including possible substitutions for current approved personnel decontamination formulations. Wide Area Decontamination: Addresses limited capabilities to rapidly restore critical DoD infrastructure (e.g., sea port or air base) and mitigate contamination spread to enable normal, unprotected operations. Efforts seek to improve contamination mitigation logistics/cost reduction, effectiveness, compatibility/safety, and environmental compatibility. Efforts support autonomous critical area biological decontamination systems. Efforts include additional investments in enhanced biodefense and pandemic preparedness.
Document Details
- Document Type
- Project
- Publication Date
- Oct 01, 2024
- Source ID
- MT3_0603384BP_3_0400_PB_2024
Related Documents
- Root: Chemical and Biological Defense Program - Advanced Development
- Child Accomplishment: 1) Biological Warfare Defense Therapeutics
- Child Accomplishment: 2) Biological Warfare Defense Therapeutics - Enhanced Biodefense (ENBD)
- Child Accomplishment: 3) Biological Warfare Defense Therapeutics
- Child Accomplishment: 4) Discovery of Medical Countermeasures Against New and Emerging (DOMANE)
- Child Accomplishment: 5) Discovery of Medical Countermeasures Against New and Emerging (DOMANE) - Enhanced Biodefense (ENBD)
- Child Accomplishment: 6) Chemical Reactive Ocular Wound and Dermal Therapeutics (CROWD)
- Child Accomplishment: 7) Emerging and Pharmaceutical-based Agent Threats (EMPATH)
- Child Accomplishment: 8) Reactivators of AChE as Therapeutics (ReACT)
- Child Accomplishment: 9) Enhanced Survivability Coatings
- Child Accomplishment: 10) Equipment Decontamination
- Child Accomplishment: 11) Multifunctional Materials for Protection
- Child Accomplishment: 12) Personnel Decontamination
- Child Accomplishment: 13) Wide Area Decontamination
- Child Accomplishment: 14) Equipment Decontamination - Enhanced Biodefense (ENBD)
- Child Accomplishment: 15) Wide Area Decontamination - Enhanced Biodefense (ENBD)